Objective: To investigate the clinical characteristics of vancomycin-induced drug fever in children

so as to provide reference for the safety of clinical drug use. Methods: Children with vancomycin-induced drug fever admitted into Wuhan Children’ s Hospital

Tongji Medical College

Huazhong University of Science & Technology from Jul. 2017 to Jun. 2021 were collected. Literature review was conducted on the case reports of vancomycin-induced drug fever in children in China

and the drug dosage

duration

adverse drug reaction symptoms and outcomes were summarized. Results: A total of 11 children with vancomycin-induced drug fever were enrolled

including 4 cases in our hospital and 7 cases reported in literature. The duration of drug fever was 5. 0 (from 2. 0 to 10. 0) d

the maximum body temperature was 39. 1 (from 38. 3 to 40. 0) ℃

and the duration of fever remission was 1. 9 (from 1. 0 to 3. 0) d

which could be accompanied by other organs and systemic adverse drug reactions. No significant increase of infection indicators was found in laboratory tests during fever

and the prognosis was good after drug withdrawal. Conclusion: Vancomycin-induced drug fever in children is difficult to distinguish from fever of infectious diseases

so it should be judged by the time of drug use

laboratory test results and fever characteristics of the children

and the suspected drug should be stopped in time to avoid severe adverse drug reactions.